Advances in the treatment of cutaneous lupus erythematosus a. An individuals own immune system attacks various cells causing a wide variety of signs and symptoms. Exfoliative cutaneous lupus erythematosus basic information description exfoliative lupus erythematosus is a generalized widespread skin disease that produces a lot of dandruff or flakiness. Acute cutaneous lupus erythematosus, chronic cutaneous lupus erythematosus, cutaneous lupus erythematosus, cutaneous, discoid lupus erythematosus, erythematosus, lupus, subacute cutaneous lupus erythematosus introduction access this article online website. Lupus erythematosus le is a chronic, autoimmune disease that includes a broad spectrum of symptoms.
However, little is known about the implication of nets in cutaneous lupus. Pdf cutaneous manifestations of systemic lupus erythematosus. Dogs with dle develop crusting and scabbing of the skin, most commonly starting around the nose, as well as a loss of skin pigmentation in the affected area. Expression of antimicrobial peptides in different subtypes. Susceptibility to develop systemic lupus erythematosus sle. Lupus erythematosus le is a chronic, autoimmune, multisystem disease that displays many diverse symptoms in which localized cutaneous le cle is on. Dubois lupus erythematosus and related syndromes ninth. Cutaneous lupus erythematosus is composed of four main types where each has their own distinct characteristics. From basic scientific principles to practical points of clinical management, the updated 9th edition provides extensive, authoritative coverage of systemic lupus. About 25% of patients with chronic cutaneous le also have systemic le discoid le. It has been classically defined as annular erythematous, succulent, plaques involving the face and trunk that typically are devoid of any papulosquamous features such as scale and follicular plugging. Systemic lupus erythematosus sle is a chronic, compli cated and challenging disease to diagnose and treat.
With regards to the skin, there are lupus specific skin lesions and nonspecific. Skin biopsy specimens of 96 study participants including 47 patients with cle 15 patients with discoid lupus erythematosus le, 11 patients with subacute cle, and 21 patients with le tumidus, 34 patients with psoriasis, and 15 healthy control subjects were evaluated in this study. Lupus erythematosus le is a multifactorial autoimmune disease with clinical manifestations. This variability confounds the development of appropriate outcome measures that are reproducible, reflect the range of patient experience and reliably. It is important to distinguish cutaneous lupus from systemic lupus erythematosus sle.
Chronic cutaneous le accounts for 80% of presentations with cutaneous le. In this autoimmune disease, the bodys immune system attacks healthy skin. This is a pdf file of an unedited manuscript that has. Discoid lupus erythematosus dle, also known as cutaneous lupus erythematosus, is an autoimmune disease that affects the skin, in which the bodys own immune system is activated to attack the body. Lupus is the latin word for wolf and has been used to name various skin diseases at least since the 10 th century. Investigating the presence of neutrophil extracellular.
Authoritative facts about the skin from dermnet new zealand. Cutaneous lupus erythematosus cle is an autoimmune skin disorder, which can occur in the context of sle or independent of other organ involvement. It is usually a welldemarcated lesion which begins as an erythematous papule or plaque and, as it progresses, develops increasing hyperkeratosis scale and scarring figure 1. Cutaneous lupus erythematosus 3 categories of lespecific skin diseases 1. Cutaneous lupus erythematosus definition of cutaneous. Validation of the cutaneous lupus erythematosus disease. A patient may be diagnosed with cutaneous lupus, but that does not mean that he or she has sle, which affects multiple parts of the body. Autoimmune disease, subacute cutaneous lupus erythematosus, discoid lupus erythematosus, acute cutaneous lupus erythematosus, sun protection, antimalarials, retinoids, thalidomide, corticosteroids definitiondiagnostic criteria lupus erythematosus le is a chronic, autoimmune, inflammatory disease that presents. The four main types of cutaneous lupus erythematosus include the following.
To date, no therapeutic agents have been licensed speci. Systemic lupus erythematosus, lahita rg ed, churchill livingstone, new york 1992. Involvement of particular organ systems over others, multisystem versus organdominant disease. Cutaneous lupus erythematosusclinical and laboratory aspects. Approximately twothirds of people with lupus will develop some type of skin disease, called cutaneous lupus erythematosus.
The most common and most severe form is systemic lupus erythematosus. Chronic cutaneous lupus ccle is most often manifested as the discoid le skin lesion dle. Cutaneous lupus erythematosus cle is lupus affecting the skin in this autoimmune disease, the bodys immune system attacks healthy skin. Le is included among the so called connective tissue diseases and is divided into one systemic form sle and one cutaneous form cle. Systemic lupus erythematosus sle is the prototypic. Lupus erythematosus le is usually divided into three major categories. Dle classically presents with erythematoustoviolaceous scaly plaques on the face and scalp with prominent follicular plugging, which often results in scarring and atrophy.
The clinical management of systemic lupus erythematosus, second edition, schur ph ed, lippincott, philadelphia 1996. It is characterized by a discshaped or coinshaped lesion. Subacute cutaneous rash pictures will show patches of reddened skin, mostly in areas often exposed to sunlight. If you have problems viewing pdf files, download the latest version of adobe reader. Cutaneous lupus erythematosus lupus is an autoimmune disease, which affects multiple organs and systems in the body. Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blood cells, heart, and lungs.
Cutaneous lupus refers to a form of the disease in which symptoms are restricted to those that affect the skin. Lupus erythematosus is a collection of autoimmune diseases in which the human immune system becomes hyperactive and attacks healthy tissues. Pdf cutaneous lupus erythematosus cle includes a variety of lupus. Pdf lupus erythematosus le is a chronic, autoimmune, multisystem disease that displays many diverse symptoms in which localized cutaneous le cle. The skin findings seen in lupus erythematosus can present with either lupus specific or lupus nonspecific findings, with lupus specific skin disease showing findings histopathologically distinct for cutaneous lupus erythematosus. Although the term is frequently used alone to designate lupus vulgaris and sometimes lupus erythematosus, without a modifier it has no meaning. Subacute and acute cutaneous lupus erythematosus are more likely to appear when systemic lupus is already present in the body. Specific for native ll37 and citrullinated ll37 that discriminate the two ll37 forms in the skin and circulation of cutaneous systemic lupus erythematosus and rheumatoid arthritis patients. Photosensitivity in cutaneous lupus erythematosus core.
Abstract neutrophil extracellular traps nets are implicated in the pathogenesis of systemic lupus erythematosus sle. Tumid lupus erythematosus tle is a rare form of chronic cutaneous lupus that has triggered much debate regarding its clinical and histopathological features. Common symptoms include painful and swollen joints, fever, chest pain, hair loss, mouth ulcers, swollen lymph nodes, feeling tired, and a red rash which is. Sorry, we are unable to provide the full text but you may find it at the following locations. It is commonly known as a discoid rash, because the areas of rash are. Discoid le or chronic le only involving the skin with scaly patches, usually in sunexposed areas 2. Abstract lupus erythematosus le is an autoimmune disease with diverse clinical manifestations ranging from limited cutaneous cle to.
Clinical manifestations of cutaneous lupus erythematosus. Discoid cutaneous lupus erythematosus vca animal hospital. Papulosquamous scle occurs in approximately two thirds of cases and consists of red scaly patches. Symptoms vary between people and may be mild to severe. Lupus specific skin diseases include chronic cutaneous. Dubois lupus erythematosus and related syndromes ninth edition. Cutaneous lupus erythematosus cle is an exemplar of a disorder requiring a multidisciplinary approach for its management. Pdf lupus erythematosus le is a chronic, autoimmune, multisystem disease that displays many diverse. Cle limited cutaneous involvement to devastating systemic disease. Subacute cutaneous lupus erythematosus subacute cutaneous lupus erythematosus scle is a distinct subset of le that identifies patients with clinically erythematous, nonscarring lesions, pronounced light sensitivity, musculoskeletal complaints, characteristic serological abnormalities and a variety of relatively mild systemic symptoms. Acute cutaneous lupus including malar rash, photosensitive lupus rash or subacute cutaneous lupus 2. Cutaneous lupus erythematosus genetic and rare diseases. Brown, phd, rd the purpose of this paper was to search the scientific literatur e for dietary compounds that alleviate or exacerbate symptoms of lupus erythematosus le in both animal and human models.
Lupus erythematosus is a chronic inflammatory autoimmune disease. Discoid le is the most common form of chronic cutaneous le. Typically, it occurs in light exposed areas of the head and neck. It has the potential to intersect with many disciplines and each can contribute to providing the optimum outcome for patients. Skin disease in lupus can cause rashes or sores lesions, most of which will appear on sunexposed areas such as the face, ears, neck, arms, and legs. Cutaneous lupus erythematosus cle is lupus affecting the skin.
It was initially reported as a hereditary disease in the german shorthaired pointer and was called lupoid dermatosis. Lupus, technically known as systemic lupus erythematosus sle, is an autoimmune disease in which the bodys immune system mistakenly attacks healthy tissue in many parts of the body. Subacute cutaneous lupus erythematosus scle the rash usually appears as red, nonitchy patches on sunexposed areas such as the upper chest and back and arms. Lupus erythematosus primary care dermatology society uk.
Note that this may not provide an exact translation in all languages dermnet nz random. The clasi cutaneous lupus erythematosus disease area. Clinical characteristics of each group are unique 8. Lupus erythematosus can be divided into three main subtypes. Dubois lupus erythematosus and related syndromes has been recognized internationally as the goto clinical reference on lupus and other connective tissue diseases. Subacute le ringshaped, red patches in sunexposed areas 3. Cutaneous lupus erythematosus encompasses a wide range of dermatologic. Chronic cutaneous lupus or discoid lupus is the most common form of cutaneous lupus erythematosus. Although there are many types of rashes and lesions sores caused by cutaneous lupus, the most common rash is raised, scaly and red, but not itchy. Cutaneous lupus erythematosus cle is an autoimmune disease of the.
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